CycloLab - Cyclodextrin Research & Development Laboratory

How can CYCLOLAB assist you?

Are you working on pharmaceutical, food, cosmetic or agricultural field and have you got analytical problems, consider making use of CYCLOLAB's services to reach the goal within the shortest time.


	CYCLOLAB offers method development and validation according to the current guidelines in the fields of: • chiral separations • analysis of cyclodextrin derivatives • short and long term stability test • interaction study • bioanalytical investigations, etc.

The lab runs instruments that are fully automated HPLCs with diode array, UV, fluorescence and RI detectors, CE with diode array UV detector and GC with FID.

Chiral separations:

Cyclodextrins are extensively used in separations due to their unique property to form inclusion compounds with other smaller hydrophobic molecules. In particular, the shape and size selectivity of cyclodextrins provides an important parameter for separations. Currently, chiral separations seem to be one of the most significant areas of application

in the use of cyclodextrins and their derivatives. (The micro scaling of existing separation technologies is one of the new trends. These techniques include various capillary techniques such as CE, micro bore-LC, micro dialysis, etc).
		Simultaneous enantioseparation of 6 pyrethroic acids with 15 mM PMMAβCD, pH 6.5, + 30 kV.

For example an electrophoresis chip operating in the Mars organic detector III will help to answer the question if there was life on Mars during the next space missions planned by NASA. The analysis of the composition of chiral amino acids will be carried out with the help of a γCD running buffer.


	CycloLab offers chiral method development and analysis with the following technics: • capillary electrophoresis • gas chromatography • HPLC

Analysis of Cyclodextrin derivatives

The characterisation of the isomer distribution and purity of cyclodextrin (CD) derivatives, their quality control and examination of their stability during storage are still a real problem. Using even the most sophisticated analytical methods the separation and identification of all components is far beyond the possibility.


	CDScreen stationary phases were invented on the basis of theoretical considerations and molecular modelling. These special columns solve the problems derived from HPLC column diversity.

Limit test of βCD in (2-hydroxy) propylated-βCD

		CycloLab offers: • analysis of parent CDs and their degradation products; • characterisation of component distribution of statistically substituted CD derivatives; • determination of residual parent CDs, and degradation products in the CD derivatives; • determination of CDs and CD derivatives in drug formulations and other complexated matrices.
Chromatograms of randomly methylated αCD (RAMEA)

Services - Analitical services