CYCLOLAB offers method development and validation according to the current guidelines in the fields of:

• chiral separations
• analysis of cyclodextrins & derivatives
• short and long term stability tests
• interaction studies
• bioanalytical investigations, etc.

CycloLab Special Analytical Service:

1. Analysis of cyclodextrin & derivatives

CycloLab can assist you in:

Chromatograms of randomly methylated αCD (RAMEA)

• analysis of parent CDs and their degradation products;


• characterisation of component distribution of statistically substituted CD derivatives;


• determination of residual parent CDs, and degradation products in the CD derivatives;


• determination of CDs and CD derivatives in drug formulations and other matrices.

Special columns for cyclodextrin analysis: CDScreen stationary phases are available from ChiroQuest www.chiroquest.org

2. Method Development for Chiral Separation by CE or HPLC






Example:
Enantioseparation of dansylated and tosylated pregabalin racemates by 6-monodeoxy-6-mono-(3-hydroxy)-propylamino-beta-cyclodextrin hydrochloride (PA-ß-CD). Beni et al.: Separation and characterization of modified pregabalins in terms of cyclodextrin complexation, using capillary electrophoresis and nuclear magnetic resonance; Journal of Pharmaceutical and Biomedical Analysis, accepted.

CycloLab tests the enantioseparation of various compounds by using the widest variety of cyclodextrin derivatives by effective method development with CE and special HPLC columns.

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